Peptide epitopes recognized by disease promoting cd4+ t...

Details Peptide epitopes recognized by disease promoting cd4+ t... Peptide epitopes recognized by disease promoting cd4+ t...

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/46 (2006.01) A61P 3/10 (2006.01) A61P 37/06 (2006.01) C07K 1/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C40B 30/04 (2006.01) G01N 33/567 (2006.01) C07K 14/74 (2006.01)

Patent

CA 2758956

The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.

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