Peptide extended glycosylated polypeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/47 (2006.01) C07K 14/00 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/24 (2006.01) C12N 15/09 (2006.01) C12N 15/62 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2412882

Glycosylated polypeptides comprising the primary structure NH~2-X-P~p-COOH wherein X is a peptide addition comprising or contributing to a glycosylation site, and P~p is a polypeptide of interest or comprising the primary structure NH~2-P~x-X-P~y-COOH, wherein P~x is an N-terminal part of a polypeptide P~p of interest, P~y is a C-terminal part of said polypeptide P~p, and X is a peptide addition comprising or contributing to a glycosylation site. The glycosylated polypeptides having improved properties as compared to the polypeptide of interest.

L'invention concerne des polypeptides glycosyl~s comprenant la structure primaire NH2-X-Pp-COOH dans laquelle X est une addition peptidique contenant un site de glycosylation ou contribuant ~ ce dernier, et Pp est un polypeptide d'int~rÚt. La structure primaire peut Útre Nh2-Px-X-Py-COOH dans laquelle Px est une partie N-terminale d'un polypeptide Pp d'int~rÚt, Py est une partie C-terminale dudit polypeptide Pp, et X est une addition peptidique contenant un site de glycosylation ou contribuant ~ ce dernier. Les polypeptides glycosyl~s poss­dent des propri~t~s am~lior~es par rapport au polypeptide d'int~rÚt.

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