Peptide for inhibiting growth of smooth muscle cells

Details Peptide for inhibiting growth of smooth muscle cells Peptide for inhibiting growth of smooth muscle cells

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/57 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/745 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232240

The present invention is directed to a peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to the C-terminal of the peptide (A) directly or via several amino acid residues. The novel peptide of the present invention inhibits the growth of smooth muscle cells. The invention is further directed to a pharmaceutical composition comprising said peptide useful for preventing or treating pathological conditions associated with the growth of smooth muscle cells such as arteriosclerosis, restenosis after angioplasty, luminal stenosis after grafting blood vessels and smooth muscle sarcoma.

L'invention porte sur un peptide contenant: un peptide formé d'une séquence d'acides aminés riche en acides aminés de base; et (B) un deuxième peptide formé d'une séquence d'acides aminés contenant au moins deux résidus consécutifs d'acides aminés hydrophobes. Le peptide (B) est fixé directement ou par l'intermédiaire d'une séquence de plusieurs acides aminés à l'extrémité C-terminale du peptide (A). Ce nouveau peptide a d'excellents effets inhibiteurs sur la prolifération des fibres de muscles lisses et les préparations le contenant sont efficaces pour la prévention ou le traitement de l'artériosclérose accompagnant la prolifération des fibres de muscles lisses, la resténose faisant suite à une angioplastie, la sténose faisant suite à une transplantation vasculaire, et le léiomyosarcome.

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