Peptide fragments and uses thereof as type-1 interferon...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 14/715 (2006.01) A61K 38/08 (2006.01) A61K 38/19 (2006.01) C07K 7/06 (2006.01) C07K 14/555 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2397267

The invention provides peptides of about 9-12 amino acids having a sequence derived from the interferon binding site of the IFNAR1 chain of the Type 1- interfereon (Type 1-IFN) receptor for use as a Type 1-IFN antagonist. In particular, the invention provides peptides having the 9 mer sequence FSSLKLNVY (Sequence ID no. 1) and analogues thereof for use as Type 1-IFN antagonists. Particularly preferred for this purpose is the peptide of Sequence ID no. 1 and analogues thereof including Sequence ID no. 1 having an additional asparagine residue (N) at the C-terminus and/or additional glutamic acid residue (E) at the N-terminus.

La présente invention concerne des peptides qui sont constitués d'environ 9-12 acides aminés, présentent une séquence dérivant du site de liaison de l'interféron de la chaîne IFNAR1 du récepteur d'interféron de type 1 (type 1-IFN) et sont destinés à être utilisés en tant qu'antagonistes de type 1-IFN. La présente invention concerne notamment des peptides présentant la séquence FSSLKLNVY 9 mer (séquence ID no. 1) et des analogues de ceux-ci, qui sont destinés à être utilisés en tant qu'antagonistes de type 1-IFN. Selon cette invention, le peptide préféré est le peptide de séquence ID no. 1 et des analogues de celui-ci, la séquence ID no. 1 comprenant un reste asparagine supplémentaire (N) à la partie C-terminale et/ou un reste acide glutamique supplémentaire (E) à la partie N-terminale.

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