Peptide fragments for inducing synthesis of extracellular...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/78 (2006.01) A61K 8/65 (2006.01) A61K 38/07 (2006.01) A61K 38/39 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 5/117 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2655116

[0049] Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

La présente invention concerne de petits tétrapeptides biologiquement actifs qui comportent les séquences GxxG et PxxP, G (glycine) et P (proline) étant constantes et x étant un acide aminé variable. Les peptides peuvent être utilisés seuls ou combinés afin de stimuler la production de protéines matricielles extracellulaires dans la peau. L'invention concerne également un procédé peu onéreux permettant de produire des formulations hétérogènes de tétrapeptides.

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