Peptide fragments of the harp factor inhibiting angiogenesis

Details Peptide fragments of the harp factor inhibiting angiogenesis Peptide fragments of the harp factor inhibiting angiogenesis

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2504270

The invention concerns peptide fragments 13-39 and 65-97 of the HARP factor, which inhibit angiogenesis. Advantageously, said peptides can be associated with the peptide 111-136 of HARP. The invention also concerns pharmaceutical compositions comprising said peptides or nucleic acids encoding said peptides, and their use for treating pathologies associated with an angiogenesis, in particular proliferative disorders such as cancer.

L'invention concerne les fragments peptidiques 13-39 et 65-97 du facteur HARP, qui inhibent l'angiogénèse. De manière avantageuse, ces peptides peuvent être associés avec le peptide 111-136 d'HARP. L'invention concerne également des compositions pharmaceutiques comprenant ces peptides ou des acides nucléiques codant pour ces peptides, et leurs utilisations pour le traitement de pathologies associées à une angiogénèse, en particulier les désordres prolifératifs comme le cancer.

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