Peptide fragments of tissue factor and their use for...

Details Peptide fragments of tissue factor and their use for... Peptide fragments of tissue factor and their use for...

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) A61K 38/04 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223143

Peptide reagents and compositions thereof which reduce blood clotting initiated by the ternary complex of tissue factor (TF), FVIIa and FXa. The peptides have the amino acid sequences Thr-Leu-Tyr-Tyr-Trp-Arg-Ala-Ser-Ser- Thr, Ile-Ile-Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr, Ile-Thr-Tyr-Arg-Lys-Gly-Ser-Ser- Thr, Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr and Gly-Gly-Thr-Tyr-Arg-Lys-Gly-Ser-Ser- Thr.

Des réactifs peptidiques, et des compositions les contenant, réduisent la coagulation du sang déclenché par le complexe ternaire constitué du facteur tissulaire (TF), de FVIIa et de FXa. Ces peptides présenent les séquences d'acides aminés Thr-Leu-Tyr-Tyr-Trp-Arg-Ala-Ser-Ser-Thr, Ile-Ile-Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr, Ile-Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr, Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr and Gly-Gly-Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr.

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