C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2723887
The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.
L'invention porte sur un peptide qui migre spécifiquement vers le modèle intracrânien du stade précoce d'astrocytome qui se développe dans le cerveau sous la forme d'îlots renfermant des vaisseaux tumoraux. Ledit peptide trouve son utilisation dans l'administration ciblée de substances thérapeutiques à des cancers du cerveau invasifs ou à des lésions cérébrales métastatiques, seul ou en association avec des thérapies conventionnelles, telles que la chirurgie et la radiothérapie et des thérapies antiangiogéniques, et comme outil diagnostique, par exemple pour le cancer du cerveau invasif ou les lésions cérébrales métastatiques.
Bergers Gabriele
Laakkonen Pirjo
Ruoslahti Erkki
Burnham Institute For Medical Research
Laakkonen Pirjo
Marks & Clerk
The Regents Of The University Of California University Of Califorina Sa N. Francisco ("ucsf")
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