Peptide hormones zalpha48 and zsig97

Details Peptide hormones zalpha48 and zsig97 Peptide hormones zalpha48 and zsig97

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12N 15/16 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2546796

The present invention relates to polynucleotide and polypeptide molecules for zalpha48 and zsig97, two proteins that define a novel peptide hormone family. The DNA encoding the peptides and the encoded peptides are useful in treating disorders of the thyroid, prostate, neural dysfunction, immune dysfunction, diseases of the pancreas, adrenal gland, ovary, and pituitary. The present invention also includes methods for producing the protein, uses therefor and antibodies therefore.

La présente invention concerne des molécules polynucléotidiques et polypeptidiques de zalpha48 et zsig97, deux protéines qui définissent une nouvelle famille d'hormone peptidique. L'ADN codant pour les peptides et les peptides codés sont utiles dans le traitement de troubles de la thyroïde, de la prostate, le dysfonctionnement neuronal, le dysfonctionnement immunitaire, les maladies du pancréas, de la glande surrénale, de l'ovaire et de l'hypophyse. La présente invention concerne également des procédés de production de la protéine, leurs utilisations et les anticorps concernés.

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