C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01) A61P 37/08 (2006.01) C07K 7/08 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2245497
Immunogenic molecules comprising (a) at least one moiety of a peptide mimicking the natural epitope on human IgE recognized by the monoclonal anti-human IgE antibody BSW17, and (b) a moiety capable of eliciting an immune response against that peptide. They are useful in, or for the preparation of, pharmaceutical compositions, particularly for the treatment of IgE-mediated diseases such as allergies and atopic dermatitis, e.g. vaccines against allergy.
L'invention concerne des molécules immunogènes comprenant (a) au moins un fragment peptidique mimétique de l'épitope naturel de l'IgE humaine reconnu par l'anticorps monoclonal anti-IgE humain BSW17 et (b) un fragment capable de provoquer une réaction immune contre ce peptide. Ces molécules sont utiles pour la préparation de compositions pharmaceutiques, en particulier pour le traitement de maladies provoquées par l'IgE telles que les allergies et l'eczéma constitutionnel. Elles sont également utiles pour réaliser des "vaccins" contre les allergies.
Kricek Franz
Stadler Beda
Fetherstonhaugh & Co.
Novartis Ag
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