C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2451089
A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. Said molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC). Said molecule is also able to inhibit in vivo angiogenesis CD1 mice.
L'invention concerne un nouveau peptide, dérivé du facteur de croissance fibroblastique humain (bFGF). Ladite molécule est capable d'inhiber in vitro les effets du facteur de croissance dérivé de plaquettes (PDGF-BB) et du facteur de croissance fibroblastique de base (bFGF) sur des cellules primaires de muscles lisses de rats (RASMC) et des cellules primaires endothéliales bovines (BAEC). Ladite molécule est également capable d'inhiber in vivo des souris CD1 d'angiogenèse.
Facchiano Angelo
Facchiano Antonio
Facchiano Francesco
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Provincia Italiana Della Congregazione Dei Figli Dell'immacolata
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