Peptide inhibitors of c-jun dimerization and uses thereof

Details Peptide inhibitors of c-jun dimerization and uses thereof Peptide inhibitors of c-jun dimerization and uses thereof

A - Human Necessities

61

K

A61K 38/02 (2006.01) C07K 2/00 (2006.01)

Patent

CA 2577995

The present invention provides a method for the screening of nucleic acid fragment expression libraries and selecting encoded peptides based upon their ability to modulate the activity of a target protein or nucleic acid and assume conserved conformations compatible with albeit not reiterative of the target protein or nucleic acid. The present invention also provides methods for the diagnosis and treatment of ischemia. The present invention also provides c-Jun dimerization inhibitory peptides and analogues thereof that are useful for treatment of ischemia.

La présente invention concerne un procédé de criblage des banques d~expression de fragments d~acides nucléiques et de sélection de peptides codés en fonction de leur capacité à moduler l~activité d~une protéine ou d~un acide nucléique cible et à conserver des conformations compatibles avec la protéine ou l~acide nucléique cible sans être des répétitions de celle/celui-ci. La présente invention concerne également des procédés de diagnostic et de traitement de l~ischémie. La présente invention concerne également des peptides inhibiteurs de la dimérisation avec c-Jun et des analogues de ceux-ci, qui sont utiles dans le traitement de l~ischémie.

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