Peptide inhibitors of cellular adhesion

Details Peptide inhibitors of cellular adhesion Peptide inhibitors of cellular adhesion

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/12 (2006.01) C07K 7/52 (2006.01) C07K 7/54 (2006.01) C07K 14/705 (2006.01) C12P 21/04 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2144180

Novel cyclic peptides of the selectin 54-63 sequence exhibit unexpected and desired properties. Specific points of cycliza- tion or conformational restriction in conjunction with specific substitutions have been identified that not only unexpectedly en- hance the biological activity of these compounds, but also significantly increase their resistance to enzymatic degradation. Formu- las of the active compounds and representative examples of preferred peptides are presented herein.

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