Peptide inhibitors of cxc intercrine molecules

Details Peptide inhibitors of cxc intercrine molecules Peptide inhibitors of cxc intercrine molecules

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2178927

Disclosed are peptide-based compositions and methods for inhibiting and modulating the actions of CXC intercrine molecules. The antileukinate peptides described inhibit IL-8, GRO and MIP2.beta. binding to neutrophils and neutrophil activation. The peptides are particularly advantageous as they inhibit IL-8-induced enzyme release at a 25 fold lower concentration than is required to inhibit chemotaxis, which makes them ideal for treating various inflammatory diseases and disorders including, amongst others, Adult Respiratory Distress Syndrome (ARDS), cystic fibrosis and chronic bronchitis.

On décrit des compositions à base de peptides ainsi que des méthodes pour inhiber et moduler l'action de molécules de la famille des intercrines CXC. Les peptides antileukine décrits inhibent la fixation de l'interleukine 8 (IL-8), de l'oncogène de croissance (GRO) et de la protéine inflammatoire de macrophages 2.beta. (MIP2.beta.) sur les neutrophiles et l'activation des neutrophiles. Les peptides sont particulièrement avantageux car ils inhibent la libération d'enzymes libérées par l'IL-8 à une concentration 25 fois plus basse que celle nécessaire pour inhiber le chimiotactisme, ce qui en fait un agent idéal pour traiter différentes maladies et affections inflammatoires et, en particulier, la détresse respiratoire chez l'adulte, la fibrose kystique et la bronchite chronique.

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