Peptide inhibitors of cyclin-dependent kinase activity and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2603132

Novel polypeptides or derivatives comprising cdk2 binding site are disclosed. The novel polypeptides or derivatives have growth suppressive activity. Nucleic acids encoding those polypeptides are also disclosed. The polypeptides identified herein are also useful in methods for treating or preventing cancer. The treatment methods comprise administration of the polypeptide to the patient. The methods also comprise contacting the sample with the above-described polypeptide or derivative, wherein the polypeptide or derivative also comprises a covalently attached detectable moiety, then determining whether the polypeptide or derivative is binding cdk2 from the sample.

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