C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01) A61K 38/39 (2006.01)
Patent
CA 2148383
2148383 9411395 PCTABS00032 Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The peptides can be used to bind to fibronectin or other related collagen-binding proteins to inhibit fibronectin-dependant cell adhesion to collagen matrices and to inhibit interactions with collagen of other proteins that share homologies with the gelatin-binding domain of fibronectin.
Guo Neng-Hua
Krutzch Henry C.
Negre Eric
Roberts David D.
Sipes John M.
Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And
Smart & Biggar
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