Peptide inhibitors of hepatitis c virus ns3 protease

Details Peptide inhibitors of hepatitis c virus ns3 protease Peptide inhibitors of hepatitis c virus ns3 protease

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/195 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/405 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) C07C 229/22 (2006.01) C07C 237/22 (2006.01) C07C 271/22 (2006.01) C07C 311/45 (2006.01) C07C 311/51 (2006.01) C07C 323/60 (2006.01) C07D 209/26 (2006.01) C07D 209/32 (2006.01) C07D 307/94 (2006.01) C07D 333/24 (2006.01) C07D 407/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07K 5/08 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006

Patent

CA 2330247

Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of the invention, optimised for binding in the S1 specificity pocket of the enzyme, may display IC50s at the sub-micromolar level. Embodiments of tripeptides of the invention, having a keto-acid group at the C-terminus are, likewise, potent inhibitors of NS3 protease.

Les oligopeptides fluorés, en particulier ceux qui comportent un acide 4,4-difluoro-2-amino butyrique au niveau du carbone terminal, peuvent être des inhibiteurs efficaces de la protéase NS3 du virus de l'hépatite C. Des exemples d'hexapeptides selon l'invention, optimisés pour leur liaison dans la poche de spécificité S1 de l'enzyme peuvent présenter IC¿50?s au niveau submicromolaire. Des tripeptides selon l'invention avec groupe ceto-acide au niveau du carbone terminal de chaîne, sont également des inhibiteurs potentiels de la protéase NS3.

Affiliated with

Also associated with

Rating

Peptide inhibitors of hepatitis c virus ns3 protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide inhibitors of hepatitis c virus ns3 protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide inhibitors of hepatitis c virus ns3 protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1663357