Peptide inhibitors of hiv entry

Details Peptide inhibitors of hiv entry Peptide inhibitors of hiv entry

C - Chemistry, Metallurgy

07

K

C07K 14/155 (2006.01) C07K 14/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2423004

Described herein are chimeric peptides comprising a soluble trimeric coiled- coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to demonstrate their ability to serve as potent anti-HIV therapeutic molecules and thus, as therapeutic molecules or drugs.

L'invention porte sur des peptides chimères comprenant une superhélice trimère soluble ou tout ou partie de la région N-peptide de gp41 du VIH. Ces molécules sont des superhélices trimères stables qui inhibent la pénétration du VIH dans les cellules telles que des cellules humaines. Ces peptides peuvent être ensuite évalués pour démontrer leur capacité à servir de molécules thérapeutiques puissantes contre le VIH et, par conséquent, de molécules thérapeutiques ou médicaments.

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