Peptide inhibitors of inflammation mediated by selectins

Details Peptide inhibitors of inflammation mediated by selectins Peptide inhibitors of inflammation mediated by selectins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C12P 21/02 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2118695

2118695 9305070 PCTABS00020 Peptides derived from three regions of the lectin domain of GMP-140 and the related selectins, ELAM-1 and the lymphocyte homing receptor, have been found to inhibit neutrophil adhesion to GMP-140. The peptides are useful as diagnostics and, in combination with a suitable pharmaceutical carrier, for clinical applications in the modulation or inhibition of coagulation processes or inflammatory processes.

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