Peptide inhibitors of lfa-1/icam-1 interaction

Details Peptide inhibitors of lfa-1/icam-1 interaction Peptide inhibitors of lfa-1/icam-1 interaction

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/12 (2006.01) C07K 1/22 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2397485

Cyclic peptides inhibit LFA-1 interaction with ICAM-1 and are useful in treatment of hematopoietic neoplasms and in adjunct therapy in prevention of retinoic acid syndrome and diseases involving emigration of leukocytes into organ tissue.

L'invention concerne des peptides cycliques inhibant l'interaction de LFA-1 avec ICAM-1, lesquels peptides conviennent pour le traitement des néoplasmes hématopoïétiques et, en thérapie adjointe, pour la prévention du syndrome de l'acide rétinoïque et de maladies impliquant l'émigration de leucocytes dans le tissu d'un organe.

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