Peptide inhibitors of mitogenesis and motogenesis

Details Peptide inhibitors of mitogenesis and motogenesis Peptide inhibitors of mitogenesis and motogenesis

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) A61K 38/45 (2006.01) C07K 1/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2142713

2142713 9501376 PCTABS00035 The invention in the field of cell biology relates to novel peptides able to interact with intracellular signal transducers, thus interfering with signal transduction pathways leading to cell proliferation and motility. The peptides of the invention may be chemically synthesized from single amino acids and/or preformed peptides of two or more amino acid residues. The peptides of the invention find a useful application in the treatment of a neoplastic disease.

L'invention se rapporte au domaine de la biologie cellulaire et concerne de nouveaux peptides susceptibles d'interagir avec des transducteurs de signaux intracellulaires, ce qui entrave les voies de transduction de signaux entraînant la motilité et la prolifération cellulaires. Les peptides de l'invention peuvent être chimiquement synthétisés à partir d'aminoacides simples et/ou de peptides préformés d'au moins deux restes d'aminoacides. Les peptides de l'invention conviennent au traitement d'affections néoplasiques.

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