C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/82 (2006.01)
Patent
CA 2057675
10/JWW2 18021IA TITLE OF THE INVENTION PEPTIDE INHIBITORS OF RAS-GAP INTERACTION ABSTRACT OF THE INVENTION Oncogenic forms of Ras protein have been reported to occur in a variety of human cancers, including colorectal carcinoma, exocrine pancreatic carcinoma, and myeloid leukemias. Active forms of Ras protein which are complexed with GTP can bind to GTPase activating protein (GAP). This binding is thought to be an important step in the cell transforming activity of Ras. According to the present invention a group of peptides have been discovered which block the binding of Ras to GAP.
Freidinger Roger M.
Garsky Victor M.
Gibbs Jackson B.
Schaber Michael D.
Sigal Irving S.
Freidinger Roger M.
Garsky Victor M.
Gibbs Jackson B.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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