Peptide inhibitors of urokinase receptor activity

Details Peptide inhibitors of urokinase receptor activity Peptide inhibitors of urokinase receptor activity

C - Chemistry, Metallurgy

12

N

C12N 15/58 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2163741

Effective urokinase-type plasminogen activator receptor antogonists have sequences selected from the group AEPMPHSLN- FSQYLWYT, AEWHPGLSFGSYLWSKT, AEHTYSSLWDTYSPLAF, AESSLWTRYAWPSMPSY, AELDLWMRHYPLSFSNR, AEWSFYNLHLPEPQTIF, AETLFMDLWHDKHILLT, AEPLDLWSLYSLPPLAM, AESLPTLTSILWGKESV, AESQTGTL- NTLFWNTLR, AESSLWRIFSPSALMMS, AEPALLNWSFFFNPGLH, AEAWFLSNTMKALSARL, AEPTLWQLYQFPLRLSG, AEISFSELMWLRSTPAF, AEWTTSSPPLTQYLWGF, AEMHRSLWEWYVPNQSA, AEIKDEKMGLWDLYSM, AEILNF- PLWHEPLWSTE, AELSEADLWITWFGMGS, AESVQYSKLWKPNTTLA, AEPLSLYQKKTLRTIFAN, AELPRTNPVTAVKNPSF, AEQLNRSIPDLQFSMFN, and AESHIKSLLDSSTWFLP, or active analogs or active portions thereof.

Antagonistes efficaces des récepteurs d'activateur de plasminogènes (du genre urokinase) présentant des séquences sélectionnées dans le groupe: AEPMPHSLNFSQYLWYT, AEWHPGLSFGSYLWSKT, AEHTYSSLWDTYSPLAF, AESSLWTRYAWPSMPSY, AELDLWMRHYPLSFSNR, AEWSFYNLHLPEPQTIF, AETLFMDLWHDKHILLT, AEPLDLWSLYSLPPLAM, AESLPTLTSILWGKESV, AESQTGTLNTLFWNTLR, AESSLWRIFSPSALMMS, AEPALLNWSFFFNPGLH, AEAWFLSNTMKALSARL, AEPTLWQLYQFPLRLSG, AEISFSELMWLRSTPAF, AEWITSSPPLTQYLWGF, AEMHRSLWEWYVPNQSA, AEIKTDEKMGLWDLYSM, AEILNFPLWHEPLWSTE, AELSEADLWITWFGMGS, AESVQYSKLWKPNTTLA, AEPLSLYQKKTLRHFAN, AELPRTNPVTAVKNPSF, AEQLNRSIPDLQFSMFN, et AESHIKSLLDSSTWFLP, ou leurs analogues actifs, ou certaines de leurs parties actives.

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