Peptide ligands of dendritic cells for nucleic acid vector...

Details Peptide ligands of dendritic cells for nucleic acid vector... Peptide ligands of dendritic cells for nucleic acid vector...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2526482

A peptide consisting of or comprising an amino acid sequence selected from a ) Px1X2X3 T [SEQ.ID.NO.:1]; b) PSX4S [SEQ.ID.NO. :2]; C) QX5X6X7Q [SEQ.ID.NO.:3]; d) SX8S [SEQ-ID.NO.:4], in which X1, X2 and X3, which may be the same or different, each represents an amino acid residue; X2 is preferably N or L; X4 represents an amino acid residue, preferably N or L; X5 and X7, which may be the same or different, each represents an amino acid residue, X6 represents an amino acid residue having an amide side chain; and X8 represent an amino acid having an aliphatic side chain, which peptide binds to dendritic cells and also to other types of cells. The peptide may be used a target non- viral and viral vectors to such cells.

L'invention concerne un peptide constitué d'une séquence d'acides aminés ou comprenant une séquence d'acides aminés choisie parmi : (a) Px?1¿X?2¿X?3¿T [SEQ.ID.NO.:1] ; (b) PSX?4¿S [SEQ.ID.NO.:2] ; (c) QX?5¿X?6¿X?7¿Q [SEQ.ID.NO.:3] ; (d) SX?8¿S [SEQ-ID.NO.:4], dans laquelle X?1¿, X?2¿ et X?3¿, pouvant être identiques ou differents, représentent chacun un résidu d'acide aminé ; X?4¿ représente un résidu d'acide aminé ; X?5¿ et X?7¿, pouvant être identiques ou différents, représentent chacun un résidu d'acide aminé, X?6¿ représente un résidu d'acide aminé comportant une chaîne latérale amide ; et X?8¿ représente un acide aminé comportant une chaîne aliphatique, dont le peptide se fixe sur des cellules dendritiques et sur d'autres types de cellules. Ce peptide peut être utilisé en tant que vecteur viral et non viral cible pour lesdites cellules.

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