Peptide/lipid complex formation by co-lyophilization

Details Peptide/lipid complex formation by co-lyophilization Peptide/lipid complex formation by co-lyophilization

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/19 (2006.01) C07K 14/775 (2006.01) A61K 9/107 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2305704

The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the peptides and lipids or two separate solutions may be lyophilized.

L'invention porte sur la formation de vésicules et de complexes peptides/lipides par co-lyophilisation des peptides, de préférence qui sont capables d'adopter une conformation alphahélicoïdale amphipathique, et d'un ou plusieurs lipides. Une solution simple qui solubilise à la fois les peptides et les lipides ou deux solutions séparées peut être lyophilisée.

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