G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/539 (2006.01) A61K 39/385 (2006.01) C07F 9/10 (2006.01) C07K 1/02 (2006.01) C07K 1/04 (2006.01) C07K 17/08 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/536 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2699366
Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl- glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.
La présente invention concerne des constructions peptidiques-lipidiques de structure L-S-F, où F est un peptide, S est un espaceur liant de manière covalente F à L par l'intermédiaire d'un oligomère d'éthylène glycol, et L est un glycérolipide de diacyle ou de dialkyle (incluant les glycérophospholipides). L'espaceur comporte idéalement de 6 à 14 unités répétitives d'éthylène glycol, correspondant au PEG, d'une masse moléculaire d'approximativement 250 à 600. L'invention concerne également un procédé de détection d'anticorps sériques réactifs par la mise en contact de sérum avec des cellules modifiées afin d'incorporer une construction peptidique-lipidique, où le peptide est un épitope de l'anticorps, et un procédé de détermination du degré d'agglutination des cellules.
Bovin Nicolai
Henry Stephen Micheal
Weinberg Cristina-Simona
Bovin Nicolai
Henry Stephen Micheal
Kode Biotech Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Weinberg Cristina-Simona
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