Peptide mutant of human erab/hadh2, its x-ray crystal...

Details Peptide mutant of human erab/hadh2, its x-ray crystal... Peptide mutant of human erab/hadh2, its x-ray crystal...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07D 487/04 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G06F 17/00 (2006.01)

Patent

CA 2354653

The identification, isolation and modification of human ERAB/HADH2 is described. A crystal structure of ERAB/HADH2 is described which may be used in the discovery, identification and characterization of inhibitors or modulators of ERAB/HADH2. This structure provides a three-dimensional description of binding sites of ERAB/HADH2 for structure-based design of inhibitors or modulators thereof as therapeutic agents, for example in the treatment of Alzheimer's disease).

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