Peptide nucleic acid conjugates and uses thereof

Details Peptide nucleic acid conjugates and uses thereof Peptide nucleic acid conjugates and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/66 (2006.01) A61K 38/02 (2006.01) A61K 48/00 (2006.01) A61P 3/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07F 9/54 (2006.01) C07K 2/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2578473

The invention provides a triphenylphosphonium peptide nucleic acid conjugate. The conjugate comprises a peptide nucleic acid linked via a disulfide bond, to a triphenylphosphonium group. Conjugates of the invention can be used to deliver PNA oligomers across the plasma membrane into cells.

L'invention concerne un conjugué d'acide nucléique peptidique de triphénylphosphonium. Ce conjugué comprend un acide nucléique peptidique lié au moyen d'une liaison disulfure à un groupe triphénylphosphonium. Lesdits conjugués peuvent servir à distribuer des oligomères PNA sur toute la surface de la membrane plasmique dans des cellules.

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