A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/28 (2006.01) A61K 38/29 (2006.01)
Patent
CA 2689358
Acid-containing oral pharmaceutical compositions are provided wherein the pharmaceutical active agents are peptide compounds (i.e., those that include a plurality of amino acids and at least one peptide bond in their molecular structures). Certain barrier layers and/or particulate coated acid are used to reduce any adverse interactions that might otherwise occur between the acid of the compositions and other components of the composition. Use of these barrier layers and/or use of particulate coated acid is believed to promote a more simultaneous release of the components of the composition than is achieved by prior art acid-protection techniques, thus enhancing, and making more consistent, the bioavailability of the active peptide compounds.
La présente invention concerne des compositions pharmaceutiques à administration orale contenant de l'acide dans lesquelles les agents actifs sont des composés peptidiques (c'est-à-dire ceux qui incluent une pluralité d'acides aminés et au moins une liaison peptidique dans leurs structures moléculaires). Certaines couches barrières et/ou un acide enrobé particulaire sont utilisés pour réduire toute interaction contraire pouvant se produire entre l'acide des compositions et d'autres composants de la composition. L'utilisation de ces couches barrières et/ou l'utilisation d'acide enrobé particulaire est censé favoriser une libération plus simultanée des composants de la composition que lorsque l'on avait recours à des techniques de protection d'acide, mettant en évidence et rendant plus compatible la biodisponibilité des composés de peptide active.
Consalvo Angelo P.
Stern William
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Unigene Laboratories Inc.
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