Peptide pharmaceutical formulations

Details Peptide pharmaceutical formulations Peptide pharmaceutical formulations

A - Human Necessities

61

K

A61K 38/30 (2006.01) A61K 38/25 (2006.01) A61K 38/26 (2006.01) A61K 38/29 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01) A61M 5/142 (2006.01)

Patent

CA 2380423

A pharmaceutical composition for administration to a mammal is disclosed. The composition includes a therapeutically effective amount of a peptide, such as a GLP-1 molecule, a PTH molecule, or a GRF molecule. The composition further includes a buffer including a weak acid having an acid dissociation constant value of greater than about 1x10-5, such as acetic acid. The composition also includes an excipient for making the composition generally isotonic, such as D- mannitol.

L'invention concerne une composition pharmaceutique destinée à être administrée à un mammifère. La composition comprend une quantité efficace sur le plan thérapeutique d'un peptide, tel qu'une molécule GLP-1, une molécule PTH ou une molécule GRF. La composition comprend en outre un tampon renfermant un acide faible ayant une valeur constante de dissociation d'acide supérieure à environ 1x10?-5¿, tel qu'un acide acétique. La composition comprend également un excipient permettant de rendre la composition généralement isotonique, telle que D-mannitol.

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