Peptide-polysaccharide-protein conjugate vaccines

Details Peptide-polysaccharide-protein conjugate vaccines Peptide-polysaccharide-protein conjugate vaccines

C - Chemistry, Metallurgy

07

K

C07K 14/22 (2006.01) A61K 39/12 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2047031

18068IA TITLE OF THE INVENTION PEPTIDE-POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES ABSTRACT OF THE DISCLOSURE Covalent conjugate immunogens, having human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides covalently bound to the Outer Membrane Protein Complex (OMPC) of Neisseria through a linker which is an anionic polysaccharide (PSA), are useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS) or for treating humans afflicted with HIV infection or HIV disease, including AIDS.

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