Peptide potentiation of acid-sensory ion channel in pain

Details Peptide potentiation of acid-sensory ion channel in pain Peptide potentiation of acid-sensory ion channel in pain

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) C07K 5/107 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2407376

An array for determining agonists, antagonists, or modulators for acid-sensing ion channels. The assay is especially useful fo screening analgesics. The screening assay can be provided in a kit form. The assay comprises administering the composition to be screened to cells expressing acid-gated channels and then determining whether the composition inhibits, enhances, or has no effect on the channels when acid is introduced. The determination can be performed by analyzing whether a current is sustained by the cells in the presence of the composition and the acid. This current can be compared to that sustained by the FMRFamide and related peptides.

Cette invention se rapporte à un dosage servant à déterminer des agonistes, des antagonistes ou des modulateurs pour les canaux ioniques de détection d'acide. Ce dosage sert en particulier au criblage d'analgésiques. Ce dosage de criblage peut être fourni sous la forme d'un kit. Ce dosage consiste à administrer la composition à cribler à des cellules exprimant des canaux à porte acide et à déterminer ensuite si la composition inhibe, stimule ou n'influence pas lesdits canaux lors de l'introduction de l'acide. On peut effectuer cette détermination en analysant si un courant est soutenu par les cellules en présence de la composition et de l'acide. Ce courant peut être comparé à celui soutenu par le FMRF amide et les peptides apparentés.

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