Peptide process

Details Peptide process Peptide process

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) C07K 1/04 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2069654

A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises (i) assembling all the amino acids of the peptide except the C-terminal aza-amino acid by conventional solid phase synthesis; (ii) cleaving the peptide from the support with hydrazine or a substituted hydrazine; and (iii) reacting the hydrazide thus released with a cyanate ion.

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