Peptide selection method

Details Peptide selection method Peptide selection method

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2420949

There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided tolerogenic peptides of myelin basic protein (MBP) selected by such a method and their use in a pharmaceutical composition and a method to treat and/or prevent multiple sclerosis.

La présente invention concerne un procédé de sélection de peptide tolérogénique selon lequel on sélectionne un peptide capable de se lier à une molécule du CMH de classe I ou II sans autre traitement. L'invention se rapporte également à un peptide sélectionné selon le procédé précité et à l'utilisation de ce dernier dans une composition pharmaceutique et un procédé destinés à traiter et/ou prévenir une maladie.

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