Peptide sequences and compositions

A - Human Necessities – 61 – K

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Details

A61K 38/01 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2699467

Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 4OkDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the subsequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

La présente invention concerne une composition polypeptidique contenant un ou plusieurs polypeptides, lesquels polypeptides sont immunogéniques chez un vertébré de sorte qu'ils amènent le vertébré à produire des cellules du système immunitaire capables de reconnaître au moins un épitope d'une fraction de protéine salivaire d'arthropode. Ladite fraction de protéine salivaire d'arthropode a une masse moléculaire de 40 kDa ou moins, et lesdits polypeptides sont sélectionnés indépendamment les uns des autres parmi : les séquences polypeptidiques de SEQ ID 1-44 ou des sous-séquences de celles-ci, les sous-séquences ayant 7 acides aminés ou plus; ou parmi les séquences polypeptidiques ayant 85 % d'homologie ou plus avec une ou plusieurs des séquences ci-dessus et contenues dans une ou plusieurs des banques de données suivantes : GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), ou les traductions des séquences codantes ('CDS translations') de celles-ci.

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