C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 1/00 (2006.01) C07K 19/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2645003
Peptide stabilizer compounds are provided that in combination with a biologically active peptide, can increase the protease elimination half-time of the biologically active peptide in vivo. The peptide stabilizer compounds are preferably in the form of peptide sequences that confer resistance to proteolysis upon conjugated biologically active peptides. Also provided is a method for the selection of novel proteolysis resistant compounds from in vitro generated libraries, and pharmaceutical compositions comprising the stabilizer compounds identified thereby.
L'invention concerne des composés de stabilisateurs de peptides en combinaison avec un peptide biologiquement actif, qui permettent d'augmenter l'élimination de la demi-vie de protéases des peptides biologiquement actifs in vivo. Les composés des stabilisateurs de peptides ont de préférence la forme de séquences peptidiques qui confèrent aux peptides conjugués biologiquement actifs la résistance à la protéolyse. L'invention concerne également un procédé destiné à la sélection de nouveaux composés résistant à la protéolyse sur la base de bibliothèques générées in vitro et des compositions pharmaceutiques comprenant les composés de stabilisateurs ainsi identifiés.
Cooley Neil
Eldridge William
Fitzgerald Kevin
Mcgregor Duncan
Isogenica Ltd
Ridout & Maybee Llp
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