C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/44, 530/1.04
C07K 1/04 (2006.01) C08F 255/02 (2006.01) G01N 33/545 (2006.01) G01N 33/547 (2006.01)
Patent
CA 1339987
A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not including optional non-reactive substitu- ents, of at least 200,000, preferably in the range of 600,000- 1,200,000 Particularly suitable polymer substrates are substrates of a polyolefin such as polyethylene The method is particularly well- suited to the compartmentalized synthesis of a multitude of peptides or proteins in a parallel and substantially simultaneous fashion. Preferred embodiments of a solid support for performing the synthesis are prepared from thin polyethylene sheet or film which has been grafted with polystyrene chains in a radical-initiated process in which the polyethylene sheet or film is immersed in a solution of optionally substituted styrene monomer in an alcohol such as methanol, the volume percentage of styrene in the solution preferably being about 30% v/v, and subjected to gamma irradiation
610012
Almdal Kristoffer
Berg Rolf H.
Holm Arne
Merrifield Robert Bruce
Pedersen Walther Batsberg
Forskningscenter Riso
Mccarthy Tetrault Llp
LandOfFree
Peptide synthesis method and solid support for use in the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide synthesis method and solid support for use in the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide synthesis method and solid support for use in the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1312999