Peptide synthesis using pepsin

Details Peptide synthesis using pepsin Peptide synthesis using pepsin

C - Chemistry, Metallurgy

12

P

195/128.7

C12P 21/00 (2006.01) C07K 7/22 (2006.01)

Patent

CA 1046441

ABSTRACT OF THE DISCLOSURE The present invention provides a process for producing a peptide having the formula X-A-B-C-Y (III) wherein A represents Ala , Gln., Asn., .omega.-BOC-Lys., Leu., Gly., Glu., Image or Pro; A may be A1 - A2 and A1 represents a hydrophilic amino acid residue and A2 represents Val., Met., Leu. or Gln.; B represents Phe., Tyr., Leu., Met., Glu., Asp., Gln., Asn or Trp.; C represents Phe., Leu., Ileu., Tyr., Cys-SBzl., Ser-OBzl., Trp. or Met.; X represents an .alpha.-amino acid protective group; an amino acid residue having N-terminal protective group or a peptide residue having N-terminal protective group; Y represents a carboxyl protective group; an amino acid residue having C-terminal protective group or a peptide residue having C-terminal protective group, which process comprises reacting a peptide having the formula X-A-B-OH (I) with an amino acid or a peptide having the formula H-C-Y (II) in the presence of enzyme pepsin. The peptides of formula III have physiological activity.

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