C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 7/00 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2667030
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or 255, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, wherein the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with the over-expression of MPHOSPH1 and/or DEPDC1, e.g. cancers, containing these peptides as an active ingredient. The peptides of the present invention can also be used as vaccines.
La présente invention concerne des peptides ayant une séquence d'acides aminés telle qu'indiquée dans les SEQ ID no : 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 ou 255, ainsi que des peptides ayant les séquences d'acides aminés susmentionnées dans lesquelles 1, 2 ou plusieurs acides aminés sont remplacés, supprimés ou ajoutés, les peptides possédant une inductibilité des lymphocytes T cytotoxiques. La présente invention concerne également des médicaments servant à traiter ou à prévenir une maladie associée à la surexpression de MPHOSPH1 et/ou de DEPDC1, par exemple de cancers, contenant ces peptides en tant qu'ingrédient actif. Les peptides de la présente invention peuvent également être utilisés en tant que vaccins.
Fujioka Tomoaki
Nakamura Yusuke
Osawa Ryuji
Shida Midori
Tsunoda Takuya
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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