Peptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/74 (2006.01) A61K 38/16 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/00 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/76 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2324981

A polypeptide of up to 50 amino acids in length is described which is suitable for use as a vaccine against a streptococcal infection. The polypeptide comprises (a) the amino acids 150-168 of protein H of S. pyogenes having the sequence QKQQQLETEKQISEASRKS; (b) an amino acid sequence for an outer membrane protein of a streptococcal strain corresponding to sequence (a); (c) a fragment of sequence (a) or (b) of six or more amino acids; or (d) a sequence comprising a sequence (a), (b) or (c) modified by deletion, insertion, substitution or rearrangement.

La présente invention concerne un polypeptide dont la longueur est constituée d'un nombre d'acides aminés pouvant atteindre les 50. Ce polypeptide convient comme vaccin contre une infection par streptocoques. Ce polypeptide réunit (a) les acides aminés 150-168 de la protéine H de S. pyogenes représentée par la séquence QKQQQLETEKQISEASRKS, une séquence d'acides aminés convenant pour une protéine de membrane externe d'une souche streptocoque correspondant à la séquence (a), (c) un fragment de la séquence (a) ou (b) fait d'au moins six acides aminés, ou (d) une séquence (a), (b) ou (c) modifiée par suppression, insertion, substitution ou réagencement.

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