Peptides

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 271/22 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 38/03 (2006.01) C07C 237/22 (2006.01) C07C 279/14 (2006.01) C07C 323/59 (2006.01) C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 233/64 (2006.01) C07K 5/023 (2006.01) C07K 7/02 (2006.01)

Patent

CA 2256516

The invention provides novel .beta.-peptides comprising 2 or more different .beta.-amino acid residues, preferably compounds of formula (I) wherein the R residues, X and n are as defined. Compounds of the invention having as few as 5 or 6, .beta.-amino acid residues exhibit stable structures in solution and the compounds generally exhibit good resistance to proteolytic degradation. The compounds of the invention provide a valuable new source of structural diversity for synthesis of biologically active compounds, e.g. for pharmaceutical uses.

L'invention se rapporte à de nouveaux beta -peptides comprenant au moins 2 restes beta -aminoacide différents, de préférence des composés de formule (I), dans laquelle les restes R, X et n sont tels que définis. Les composés selon l'invention qui présentent un nombre de restes beta -aminoacide aussi bas que 5 ou 6 ont des structures stables en solution et présentent généralement une bonne résistance à la dégradation protéolytique. Les composés selon l'invention constituent une nouvelle source précieuse de composés à diversité structurelle accrue pour la synthèse de composés biologiquement actifs, destinés à des usages pharmaceutiques, par exemple.

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