C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.04
C07K 5/04 (2006.01) C07K 5/02 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1276390
Abstract New peptides of the formula X-Z-W-E-W'-Y are disclosed. According to one preferred embodiment X is H, POA, BOC, 4-phenylbutyryl, 2-benzyl-4-phenylbutyryl or CBZ, Z is absent or is His, Phe-His, Pro-Phe-His or His-Pro-Phe-His, W is (a) -NH-CH3-CHOH-CH2-CO- or (b) -NH-CHR3-CH(NH2)-CH2-CO-, E is absent or is Ile or Leu, W' is (a) -NH-CHR3-CH(NH2)-CH2-CO- or (b) -NH-CHR3-CHOH-CH2-CO-, R3 is isobutyl, benzyl or cyclo- hexylmethyl and Y is OH or OME, or W'-Y is also Image The peptides and their salts inhibit the activity of human plasma renin.
505553
Holzemann Gunter
Jonczyk Alfred
Minck Klaus-Otto
Raddatz Peter
Radunz Hans-Eckart
Fetherstonhaugh & Co.
Holzemann Gunter
Jonczyk Alfred
Merck Patent Gesellschaft Mit Beschraenkter Haftung
Minck Klaus-Otto
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