Peptides and a process for their preparation

Details Peptides and a process for their preparation Peptides and a process for their preparation

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 14/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1182448

- 1 - Abstract: New peptides and a process for their preparation The invention relates to peptides, the units of which can be characterized as follows: basic-basic-acid-hydrophobic-hydrophobic. of the formula A - B - S - X - Y in which A denotes arginine, lysine, ornithine or nomo- arginine, in each case in the L- or D-configuration, or .omega.-aminoalkanoyl, .omega.-guanidinoalkanoyl or .omega.-dimethylamino- alkanoyl which has 3-6 C atoms and optionally contains an .alpha.-amino group in the D- or L-configuration which in turn can carry alkanoyl having 1-6 C atoms, aroyl having 7-11 C atoms, cycloalkanoyl having up to 2 alkyl C atoms and 5-7 cycloalkyl C atoms, aralkanoyl having up to 9 C atoms altogether, wherein a -CH2- group can be replaced by -O- or -S-, alkyloxycarbonyl or aralkyloxycarbonyl having up to 7 C atoms or succinoyl, succinamoyl, glutaroyl, glutaminyl, pyroglutamyl, phthaloyl, phthalamidyl or 2-carboxybenzoyl, B denotes a basic aminoacid, preferably L-lysine, L-arginine, L-homo- arginine or L-ornithine, X denotes L-valine or L-iso- leucine and Y denotes an L- or D-aminoacid having a hydrophobic side chain or an ester, amide, alkylamide or alkyl ester having 1-6 C atoms or aralkylamide or aralkyl ester having 7-10 C atoms, thereof and S denotes Glu, D-Glu, D-Asp or D-.alpha.--aminoadipic acid The peptides can be synthesized in accordance - 1 a - with the known methods of peptide synthesis and are suitable for influencing the maturing of T-lymphocytes.

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