Peptides and antibodies that inhibit integrin-ligand bindin g

Details Peptides and antibodies that inhibit integrin-ligand bindin g Peptides and antibodies that inhibit integrin-ligand bindin g

C - Chemistry, Metallurgy

12

N

167/139, 195/1.1

C12N 5/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2000048

23158-1599 ABSTRACT Polypeptides which are derived from the Arg-Gly- Asp (RGD) binding portion of an Integrin beta subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-peptide antibodies, hybridomas secreting these antibodies, as well as methods of making and using such antibodies, and recombinant DNA molecules that define the structural gene coding for the polypeptides are also contemplated as within the scope of the present invention.

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