Peptides and antibodies that inhibit integrin-ligand binding

Details Peptides and antibodies that inhibit integrin-ligand binding Peptides and antibodies that inhibit integrin-ligand binding

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2069902

2069902 9107977 PCTABS00005 Polypeptides derived from the ligand-binding portion af an Integrin alpha subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-peptide antibodies, hybridomas secreting the antibodies, as well as methods of making and using such antibodies and recombinant DNA molecules coding for the polypeptides are also described. The polypeptides and antibodies to the polypeptides are effective inhibitors of fibrinogen binding to platelets.

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