C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2581110
The invention relates to peptides of the 60-kDa human heat shock protein, which form epitopes for T-cells, as well as peptides derived therefrom, which are modified at the contact sites with the MHC molecule and which can be used to induce peripheral tolerance mechanisms, in particular mechanisms that induce anergy or mechanisms that are mediated by regulatory T-cell clones in patients with rheumatoid arthritis. The invention also relates to pharmaceutical compositions which comprise such peptides and which are intended for the treatment of rheumatoid arthritis.
Peptides de la protéine humaine de stress thermique de 60 kDk constituant des épitopes pour les lymphocytes T et peptides dérivés de ceux-ci, lesquels sont modifiés dans les sites de contact avec la molécule MHC, et utilisés pour induire des mécanismes de tolérance périphérique, plus particulièrement des mécanismes inducteurs d'anergie ou induits par des clones de lymphocytes T régulateurs chez des patients souffrant d'arthrite rhumatoïde. Compositions pharmaceutiques comprenant de tels peptides pour le traitement de l'arthrite rhumatoïde.
Barbera Betancourt Ariana
Cosme Diaz Carelia
Del Carmen Dominguez Horta Maria
Hernandez Garcia Ariadna
Lopez Marin Nelia
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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