Peptides and compounds that bind to the thrombopoietin receptor

Details Peptides and compounds that bind to the thrombopoietin receptor Peptides and compounds that bind to the thrombopoietin receptor

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 7/02 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223449

Receptor are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

L'invention concerne des peptides et des mimétiques de peptides se fixant au récepteur de thrombopoïétine et activant ledit récepteur. Ces peptides et ces mimétiques de peptides sont utiles dans des procédés de traitement de maladies hématologiques et, en particulier, de la thrombocytopénie provoquée par la chimiothérapie, par la radiothérapie ou par les transfusions de moëlle osseuse, ainsi que dans des procédés diagnostiques mettant en application des peptides et des mimétiques de peptides marqués.

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