C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61K 38/08 (2006.01) A61K 38/39 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2409546
The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with a 3.beta. 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing .beta. ig-h3, wound healing, tissue regeneration and metastasis inhibition.
L'invention concerne des peptides et leurs dérivés présentant une activité de fixation, de propagation et d'ablation cellulaire. L'invention concerne en particulier les peptides NKDIL et EPDIM et leurs dérivés favorisant l'activité de fixation cellulaire par interaction avec une intégrine 3.beta. 1 comme récepteur cellulaire fonctionnel, et comprenant de l'acide aspartique et de l'isoleucine, essentiels dans l'activité de fixation et d'ablation cellulaire. Les peptides de l'invention et leurs dérivés peuvent être utilisés dans une étude sur l'activité de fixation cellulaire associée à diverses protéines de la matrice extracellulaire contenant .beta. ig-h3, la cicatrisation, la régénération tissulaire et l'inhibition des métastases.
Kim In-San
Kim Jung-Eun
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Regen Biotech Inc.
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