A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/03 (2006.01) A61K 38/04 (2006.01) A61K 38/10 (2006.01) C07K 7/04 (2006.01) C07K 7/08 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2355399
The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
L'invention porte sur des peptides et analogues de peptides obtenus à partir de la protéine HFE et leur utilisation dans le traitement de maladies dues à un excès de fer. Elle porte en particulier sur des peptides et analogues de peptides obtenus à partir de région alpha-1 de la protéine HFE qui réduisent l'affinité de fixation du récepteur de la transférine pour la transférine. Lesdits composés imitent la fonction de la protéine HFE et diminuent la fixation et/ou l'accumulation de fer dans les cellules.
Bennett Melanie
Bjorkman Pamela J.
Feder John N.
Lebron Jose
Schatzman Randall C.
Bio-Rad Laboratories Inc.
California Institute Of Technology
Osler Hoskin & Harcourt Llp
Progenitor Inc.
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