Peptides and pharmaceutical compositions comprising said...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2481399

Peptides comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion of at least one amino acid in the N-terminal side have an effect of inhibiting angiogenesis in cancer cells and inhibit the proliferation of the cancer cells due to the inhibitory effect. These peptides are usable in treating cancer such as stomach cancer, colon cancer, pulmonary cancer, ovarian cancer, liver cancer and pancreatic cancer

L'invention concerne des peptides qui contiennent une séquence d'acides aminés obtenue de la séquence d'acides aminés représentée par SEQ ID NO : 1 par délétion d'au moins un acide aminé du côté N-terminal. Ces peptides ont un effet inhibiteur sur l'angiogenèse dans les cellules cancéreuses, et par conséquent, ils empêchent la prolifération des cellules cancéreuses. Ces peptides sont utilisés pour traiter le cancer, notamment le cancer de l'estomac, le cancer du côlon, le cancer des poumons, le cancer des ovaires, le cancer du foie et le cancer du pancréas.

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